w.s.p
(For vet use only )
Composition:-
Each 100 gm of Colistin Sulphate City Contains: –
480 000 000 IU (20 gm) colistin sulfate (Equivalent to 16 gm colistin base)
Properties:-
Colistin is a polypeptide antibiotic belonging to the class of polymyxins.
Colistin exerts a bactericidal action on sensitive bacterial strains by disruption of their cell membrane, leading to alteration of the cell permeability and thus to a loss of intracellular material.
Colistin has a bactericidal against a wide spectrum of Gram-negative bacteria, including Enterobacteriaceae, especially Escherichia coli.
Colistin has very little activity against Gram-positive bacteria and fungi.
Gram-positive bacteria, some species of gram-negative bacteria such as Proteus and Serratia are naturally resistant to colistin.
However, the development of resistance of gram-negative enteric bacteria to colistin is rare and explained by single mutation.
Indication:-
Calves:
Treatment of gastrointestinal infections (bacterial interitis) caused by Escherichia coli and Salmonella susceptible to colistin.
Rabbits:
Treatment of gastrointestinal infections(bacterial interitis) caused by Escherichia coli and Salmonella susceptible to colistin.
Poultry:
Treatment of gastrointestinal infections(bacterial interitis) caused by Escherichia coli and Salmonella susceptible to colistin.
Target species:
Calves, rabbits and poultry.
Dosage and Administration :-
Orally in drinking water.
Dose of active
Calves and rabbits:
100 000 IU of colistin (as sulfate) per kg body weight per day in two equally divided doses for 3 days orally in milk, milk replacer, the liquid food or water of beverage.
poultry:
75 000 IU of colistin (as sulfate) per kg body weight per day orally in drinking water for 3 days
Dose of whole product:
Calves and rabbits:
20.8 mg / kg body weight
per day in two equally divided doses for 3 days orally in milk, milk replacer, the liquid food or water of beverage.
Poultry:
1.56 gm /100 kg body weight
= 1.56 gm for 10 litter drinking water daily for 3 days
Precautions for use:
Powder for oral solution that is intended to be dissolved in the milk, the liquid food or water and can not be used as such.
Warning : Non in recommended dose.
Withdrawal period :-
Meat and offal: 7 days.
Eggs: zero days.
Storage Condition:
Store in a cool, day place away from sunlight .
Packaging :-
Polythilene bag 50gm, 100gm ,500gm and 1 kg in a tin pack .